Telomeres, Soda and Long Life?

The Washington Post picked up on a study linking consumption of sugared soda with DNA telomere length.    The study claims that this link implies a link between sugared soda consumption and aging. The most dramatic claim as described by the WP is the following:

According to the research, drinking a 20 ounce bubbly beverage every day is linked to 4.6 years of additional aging.  You get the same effect by smonking, said UCSF postdoctoral fellow Cindy Leung, lead author of the study.  About 21 percent of the sample said they drank at least that much soday per day.  However, researchers say, a link does not mean causation.

Many other outlets picked up the story.  Headlines included That Sweet Drink May Age You (CNN), Drinking Sugary Soda Makes Your Cells Age Faster, Study Suggests (Huffington Post), Perils of Drinking Sugary Soda: Weight Gain, Cavities, Shortened Lifespan and What? (Dallas News) and so on.

But are these claims justified.  Most of the media simply reported the claims of the researchers as described in a post on the web site home page of their institution (UC San Francisco).  In fact, the connection between telomere length and health is controversial as pointed out by Daniel Engbar at Slate in a piece headlined, Does Drinking Soda Really Age Your Cells?  His answer to the headline is given in a sub-heading: How the Science of Telomeres Turned into a Spurious Health Trend.  According to this Slate piece the basic science of telomeres is that they are strings of nucleic acid molecules at the ends of our genetic strands of DNA whose function is to keep the very long DNA strands from unraveling.  These telomeres get shorter every time the cell divides until they disappear and the cell line dies.That much is uncontroversial.  However, the connection between measured telomere lengths and any aspect of health or even aging is tenuous at best.  Engbar's position is:

The shallow write-ups and inveigling headlines are insulting, and possibly injurious. In this case, though, they’re less offensive than the underlying science. The newly published paper delivers a mishmash of suspect stats and overbroad conclusions, marshaled to advance a theory that’s both unsupported by the data and somewhat at odds with existing research in the field. Its authors are less concerned with the health effects of drinking soda than with their broader project to establish a still new and fuzzy concept—“cellular aging”—as a pole star for public health.

Engbar also points out that the study authors stand to gain from book sales, speaking fees and product endorsements if they can persuade the public to accept their assertions about telomere lengths and health.

This is a good example of the extent to which media reports of science need to be considered carefully.

The Chemistry Behind Glow Sticks

Did you know that glow sticks were originated when a scientist tried to replace the natural bioluminescent light that fireflies made?  This dates all the way back to around the 1960's when scientist Edwin Chandross, discovered through his experiments what chemical process was needed to occur in order for the glow stick to successfully illuminate.  A lot of people are very much aware of what glow sticks are, but no one really understands the chemistry behind what makes it glow.

Inside the glow stick are two different chemical solutions, one of them being diphenyl oxalate, with a certain dye depending on what color you want the glow stick to glow.  Then on the other side of the glow stick is the hydrogen peroxide.  When one snaps the glow stick in the middle, the diphenyl oxalate is oxidized by the hydrogen peroxide which then produces the unstable compound (1,2-dioxetanedione).  This is the reaction called chemiluminescence and when the reaction dies out, the glow stick will stop illuminating.

Quick Facts:

• To make your glow stick last longer, stick it in the fridge! Cooler temperatures means a slower reaction, hence a longer glow!
• Skin contact with these chemicals inside the glow stick can lead to irritation and dermatitis

Article Link Here

Lighting up the Brain

Imaging the brain has been notoriously difficult. Most methods require the subject to be dead, if not they are very inaccurate. This article discusses a new method of brain imaging that allows accurate images of brain tissue while the subject is alive and there is no need for a label, like a dye. There is a catch however, this method cannot penetrate the skull, so at the moment human application is limited to images during open brain surgery. However this opens up many exciting research options in animals. While this technology is still pretty new it has a lot of room for development. I thought it was pretty relevant considering that the Nobel Prize was given out this year due to advancements in spectroscopy and we just watched a movie about the development of staining. This technology can allow for non invasive imaging of a living brain. This can greatly aid advances in neuroscience, and the help unravel the mysteries of the brain.

Series G Nerve Gases

The G series nerve gas was discovered in Germany in the 1930s and 1940s.  This series of nerve gases includes Tabun, Soman, Sarin, and Clyclosarin.  All series G gases are tasteless, colorless and odorless in their pure form, but impurities often give them a yellow-brown color and a faint odor.  The G series gases attack their victims either as airborne gases or through skin contact.  The G series gases all exhibit the same toxic effects.  They all inhibit the breakdown of the neurotransmitter acetylcholine.  This chemical is responsible for telling the muscles to contract.  When its breakdown is prevented then the muscle fails to relax which leads to a number of other effects.  Antidotes to nerve agents do exist, but they are often poisonous as well.  Atropine is commonly used as a component of antidotes because of its ability to block acetylcholine receptors.  Despite international agreements prohibiting the uses of dangerous gases in warfare, the nerve agents have still seen use in combat situations.  The most recent uses of nerve gases confirmed by the UN happened in Syria in 2013.  An estimated 1700 civilians may have been killed by Sarin.

 

First Human Trials of Stem Cell Therapies

Stem cell treatments have been used with a plethora of diseases and conditions experimentally and in trial. Some of these include; diabetes, Alzheimer’s, osteoarthritis, and spinal cord injury repair. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce more stem cells. In a recent article, a young woman paralyzed from a motor vehicle accident successfully underwent the first in-human experimental procedure. The hope is that the placed neural stem cells will bridge the gap created by the injury, replace severed nerve connections and restore motor/sensory function. UC San Diego Moores Cancer Center and the Sanford Cell Clinical Center (where the procedure took place) are the leading research institutes when it comes to stem cells. They have hopes for continued research and procedures with other disease such as Type 1 diabetes and chronic lymphocytic leukemia.

http://www.sciencedaily.com/releases/2014/10/141020141535.ht

 

Zaina Banihani

 

Oxygen-Free Recycling Technique Could Keep Tons of Plastics from Landfills

 

 Pyrolysis, the process of turning plastics into diesels and oils, is being used to keep non-recycled plastics from going straight to a landfill. A new analysis by the American Chemistry Council stated that a large use of this technique could generate billions of dollars and thousands of jobs all while saving the environment. The process used is fairly simple. They take mixed plastic polymers without much sorting, convert them to a liquid hydrocarbon in an oxygen free environment, and then refine the hydrocarbon into diesel and fuel. The two major industry leaders are located in Ohio and London. They are rapidly expanding and developing new technologies. The article states that "when operating at full capacity each unit handles 60 tons of plastic per day, which equates to 1.4 million liters per year of transportation fuel." The technology is up and running it is just going to take some time to get it to the market, but it is good to see this industry taking an initiative towards a cleaner environment. For more info, click here for one of the company's website.